Four-in-One and The Some -- Meet Credelio Quattro
Why your pet's protection might need an upgrade...

Q: My pet is already on Simparica, Nexgard, or Bravecto. Why are you recommending Credelio Quattro instead?Great question! All of those preventions — Simparica, Simparica Trio, Nexgard, Nexgard Plus, and Bravecto — belong to the same drug family called isoxazolines. The main difference is the specific molecule used.
Credelio Quattro’s active ingredient is lotilaner, which is considered the safest molecule in this class. It’s so safe that it’s even used in human medicine! This gives your pet strong, fast-acting parasite protection with an excellent safety profile.
Q: How fast do ticks transmit disease?
It depends on the disease. One of the most common tick-borne diseases in Alabama is Ehrlichiosis, spread by the Lone Star Tick. This tick can transmit Ehrlichia in as little as 3 hours after biting.
Credelio Quattro starts killing ticks in as little as 2 hours, working through neuromuscular breakdown to stop them before they can pass on disease.
Q: What is Ehrlichiosis, and why should I be concerned?
Ehrlichia spp. is a disease that can infect dogs, cats, and even people (that’s right — it’s zoonotic). Symptoms in pets can include fever, low energy, depression, loss of appetite, and weight loss.
Preventing ticks from biting — and killing them quickly if they do — is the best way to protect your whole family.
Q: How common is Ehrlichiosis here?
In 2025, statewide in Alabama, 1 in 30 dogs tested positive for Ehrlichia, according to the Companion Animal Parasite Council (CAPC).
Madison County: 1 in 50 dogs
Limestone County: 1 in 30 dogs
The reason Madison County numbers are lower is because more owners are consistently using tick prevention that works fast enough to stop transmission. Credelio Quattro is the only isoxazoline proven to kill the Lone Star Tick the fastest — and it lasts twice as long in the body as similar products.
Q: Does Credelio Quattro protect against other ticks?
Yes! It also kills ticks that spread Lyme Disease and Anaplasmosis.
Q: What else does Credelio Quattro protect against?
It’s more than just a tick killer — it’s an all-in-one monthly chew that protects against:
- Heartworm disease
- Fleas
- 3 species of tapeworms
- Roundworms
- Hookworms
It starts protecting against heartworm disease from the very first dose.
Q: What’s this “manufacturer guarantee” you mentioned?
When purchased through our clinic or our trusted online pharmacy (Vetcove Home Delivery), Elanco — the manufacturer — guarantees the product. That means if your pet develops a parasite or disease listed on the label despite using Credelio Quattro as directed, Elanco will pay for testing and treatment (up to a set dollar amount).
If you buy from a third-party pharmacy that isn’t connected to our clinic, you’d need to file the claim yourself.
Q: Do I need a heartworm test before starting Credelio Quattro?
If your pet has been on another prevention and is 4 months or older, we’ll do a heartworm test 6 months after starting Credelio Quattro. No test is needed right before starting unless doses have been missed.
Q: What if I miss a dose?
If you miss a dose, your pet will need to be retested for heartworms 6 months after restarting the prevention to keep the manufacturer guarantee active.
Bottom line: Credelio Quattro works faster, lasts longer, and protects against more parasites than most preventions. In Alabama, where ticks and heartworms are a year-round concern, it’s one of the best tools we have to keep your pet safe and healthy.
📞 If you’d like to learn more or find out if Credelio Quattro is right for your pet, call us or send us a message today — we’re happy to help!





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